Cardiovascular
- Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock
- Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism
- Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome
- Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical Patients
Clinical ICU
- Intensive versus Conventional Glucose Control in Critically Ill PatientsFluids & Resuscitation
- Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial
- A Decade of Reversal: An Analysis of 146 Contradicted Medical Practices
- Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial
- Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol: A Randomized Controlled Trial
- Nighttime Intensivist Staffing and Mortality among Critically Ill Patients
- Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical Patients
- A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
- Intensive Care Unit Bed Availability and Outcomes for Hospitalized Patients With Sudden Clinical Deterioration
- Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation
- Effect of Early vs Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation
- A Randomized Trial of Nighttime Physician Staffing in an Intensive Care Unit
- Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial.
- Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial.
- Comparison of Dopamine and Norepinephrine in the Treatment of Shock
- Effects of Patient-Directed Music Intervention on Anxiety and Sedative Exposure in Critically Ill Patients Receiving Mechanical Ventilatory Support
- Intensive Insulin Therapy in the Medical ICU
- Long-Term Cognitive Impairment after Critical Illness
- Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial
- Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium
- Evaluating the transition from dexmedetomidine to clonidine for agitation management in the intensive care unit
Fluids & Resuscitation
- A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit
- A MULTICENTER, RANDOMIZED, CONTROLLED CLINICAL TRIAL OF TRANSFUSION REQUIREMENTS IN CRITICAL CARE
- Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care
- Hydroxyethyl Starch 130/0.42 versus Ringer’s Acetate in Severe Sepsis
- Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest
- Mortality after Fluid Bolus in African Children with Severe Infection
- Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest
- Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
- Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial
- Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest
- Trends in Survival after In-Hospital Cardiac Arrest
Microbiology
- Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial
- Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock.
- Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.
- Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial.
- Targeted versus Universal Decolonization to Prevent ICU Infection
- Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
- International Study of the Prevalence and Outcomes of Infection in Intensive Care Units
Neuro
- A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury
- Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage
- Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial
- Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage
- Hypothermia for Neuroprotection in Convulsive Status Epilepticus
Nutrition
- Early versus Late Parenteral Nutrition in Critically Ill Adults
- Early Parenteral Nutrition in Critically Ill Patients With Short-term Relative Contraindications to Early Enteral Nutrition
A Randomized Controlled Trial - A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness.
- A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
- Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
Renal
Respiratory
- Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
- Prone Positioning in Severe Acute Respiratory Distress Syndrome
- Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial
- Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
- Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial
- Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
- Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome
- High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
- High-Frequency Oscillation for Acute Respiratory Distress Syndrome
- Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding
- Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
- Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome
- Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome
- Comparison of the Berlin Definition for Acute Respiratory Distress Syndrome with Autopsy
Sepsis
- Hydrocortisone Therapy for Patients with Septic Shock
- A Randomized Trial of Protocol-Based Care for Early Septic Shock
- Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial
- Comparison of Dopamine and Norepinephrine in the Treatment of Shock
- Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial
- Drotrecogin Alfa (Activated) in Adults with Septic Shock
- High versus Low Blood-Pressure Target in Patients with Septic Shock
- Albumin Replacement in Patients with Severe Sepsis or Septic Shock
- Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy: A Randomized Clinical Trial
- Corticosteroid Treatment and Intensive Insulin Therapy for Septic Shock in Adults
- Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
- Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults
- Prone Positioning in Severe Acute Respiratory Distress Syndrome
- Fever Control Using External Cooling in Septic Shock
- Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
- Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
- Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012
- Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock
- 2nd Publication – Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock
- Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
- A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients
Surgical
- Early versus late necrosectomy in severe necrotizing pancreatitis
- Intraoperative High-Dose Dexamethasone for Cardiac Surgery