Cardiovascular

• Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock

• THE EFFECT OF SPIRONOLACTONE ON MORBIDITY AND MORTALITY IN PATIENTS WITH SEVERE HEART FAILURE

• Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism
• Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome
• Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical Patients

Clinical ICU

• DAILY INTERRUPTION OF SEDATIVE INFUSIONS IN CRITICALLY ILL PATIENTS UNDERGOING MECHANICAL VENTILATION

• Intensive versus Conventional Glucose Control in Critically Ill PatientsFluids & Resuscitation
• Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial
• A Decade of Reversal: An Analysis of 146 Contradicted Medical Practices
• Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial
• Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol: A Randomized Controlled Trial
• Nighttime Intensivist Staffing and Mortality among Critically Ill Patients
• Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical Patients

• INTENSIVE INSULIN THERAPY IN CRITICALLY ILL PATIENTS

• A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
• Intensive Care Unit Bed Availability and Outcomes for Hospitalized Patients With Sudden Clinical Deterioration
• Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation
• Effect of Early vs Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation
• A Randomized Trial of Nighttime Physician Staffing in an Intensive Care Unit
• Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial.
• Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial.
• Comparison of Dopamine and Norepinephrine in the Treatment of Shock
• Effects of Patient-Directed Music Intervention on Anxiety and Sedative Exposure in Critically Ill Patients Receiving Mechanical Ventilatory Support
• Intensive Insulin Therapy in the Medical ICU
• Long-Term Cognitive Impairment after Critical Illness
• Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial
• Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium
• Evaluating the transition from dexmedetomidine to clonidine for agitation management in the intensive care unit

Fluids & Resuscitation

• A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit
• A MULTICENTER, RANDOMIZED, CONTROLLED CLINICAL TRIAL OF TRANSFUSION REQUIREMENTS IN CRITICAL CARE
• Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care
• Hydroxyethyl Starch 130/0.42 versus Ringer’s Acetate in Severe Sepsis
• Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest 
• Mortality after Fluid Bolus in African Children with Severe Infection

• TREATMENT OF COMATOSE SURVIVORS OF OUT-OF-HOSPITAL CARDIAC ARREST WITH INDUCED HYPOTHERMIA

• MILD THERAPEUTIC HYPOTHERMIA TO IMPROVE THE NEUROLOGIC OUTCOME AFTER CARDIAC ARREST

• Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest
• Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
• Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial
• Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest
• Trends in Survival after In-Hospital Cardiac Arrest

• Fluid overload, de-resuscitation, and outcomes
  in critically ill or injured patients: a systematic review with suggestions for clinical practice

Microbiology

• Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial

• Decontamination of the Digestive Tract and Oropharynx in ICU Patients

• Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock.

• Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock.

• Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.
• Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial.
• Targeted versus Universal Decolonization to Prevent ICU Infection
• Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
• International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

Neuro

• A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury
• Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage
• Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial
• Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage
• Hypothermia for Neuroprotection in Convulsive Status Epilepticus

• Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension

Nutrition

• Early versus Late Parenteral Nutrition in Critically Ill Adults
• Early Parenteral Nutrition in Critically Ill Patients With Short-term Relative Contraindications to Early Enteral Nutrition
  A Randomized Controlled Trial
• A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness.
• A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
• Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

Renal

• Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury

• Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial

• Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial

Respiratory

• Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
• Prone Positioning in Severe Acute Respiratory Distress Syndrome
• Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial
• Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
• Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial
• Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
• Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome
• High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
• High-Frequency Oscillation for Acute Respiratory Distress Syndrome
• Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding
• Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
• Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome
• Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome
• Comparison of the Berlin Definition for Acute Respiratory Distress Syndrome with Autopsy

• Hydrocortisone Therapy for Patients with Septic Shock
• A Randomized Trial of Protocol-Based Care for Early Septic Shock
• Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial
• Comparison of Dopamine and Norepinephrine in the Treatment of Shock
• Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial
• Drotrecogin Alfa (Activated) in Adults with Septic Shock
• High versus Low Blood-Pressure Target in Patients with Septic Shock
• Albumin Replacement in Patients with Severe Sepsis or Septic Shock
• Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy: A Randomized Clinical Trial
• Corticosteroid Treatment and Intensive Insulin Therapy for Septic Shock in Adults
• Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
• Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults
• Prone Positioning in Severe Acute Respiratory Distress Syndrome
• Fever Control Using External Cooling in Septic Shock
• Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
• Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock

• Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis

• Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012
• Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock
• 2nd Publication – Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock
• Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
• A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients

Surgical

• Early versus late necrosectomy in severe necrotizing pancreatitis
• Intraoperative High-Dose Dexamethasone for Cardiac Surgery

Trauma

• The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients