AMACING

In high-risk patients receiving contrast medium, does prophylactic hydration with normal saline compared to no prophylaxis impact the rate of contrast-induced nephropathy?

 

ATHOS-3

In patients with refractory vasodilatory shock does the addition of angiotensin II improve blood pressure compared with standard vasopressor therapy?

CHEETAH

In patients undergoing cardiac surgery with left ventricular dysfunction, does levosimendan compared to placebo reduce mortality?

CHOUDHURY

In patients with cirrhosis and septic shock does terlipressin in comparison with noradrenaline improve haemodynamic parameters?

DEMOULE

In intubated patients recovering from acute respiratory failure, does neurally adjusted ventilator assist mode (NAVA) compared to pressure support mode, (PSV) lead to fewer patients returning to assist-control ventilation?

DESIRE

In ventilated patients with sepsis, does a sedation strategy with dexmedetomidine compared with no dexmedetomidine improve mortality and number of ventilator-free days?

DETSKY

What is the discriminative accuracy of physicians and nurses in predicting 6-month mortality and functional outcomes of critically ill patients?

EL-ADAWI

In adult patients with severe sepsis, does methylene blue compared to vasopressin reduce noradrenaline requirement and increase blood pressure?

FERRIE

In critically ill adult patients receiving parenteral nutrition, does high amino acid intake compared with standard level amino acid intake, result in greater hand grip strength at ICU discharge?

Hernandez-2

In critically ill patients who are at high risk for re-intubation, is high flow nasal oxygen non-inferior to non-invasive ventilation in reducing re-intubation and post-extubation respiratory failure?

 

HYBERNATUS

In patients with convulsive status epilepticus, does the addition of therapeutic hypothermia to standard care improve neurological outcomes?

IPHIVAP

In adult mechanically ventilated patients, does inhaled heparin compared to inhaled saline or usual care reduce the incidence of ventilator acquired pneumonia (VAP)?

IRONMAN

In critically ill patients who are anaemic, does early administration of intravenous iron compared to placebo reduce the requirement for blood transfusion?

 

Kentish-Barnes

Among relatives who died in the Intensive Care Unit (ICU), does a condolence letter from a clinician, compared to no condolence letter, effect grief symptoms?

 

LARS-ANDERSON

In adult patients with in-hospital cardiac arrest, is tracheal intubation associated with survival to hospital discharge?

LEVO-CTS

In patients with a left ventricular ejection fraction (LVEF) ≤35%, undergoing cardiac surgery, does levosimenden compared with placebo reduce the incidence of a composite outcome of:

• death at day 30
• renal replacement therapy (RRT) at day 30
• perioperative myocardial infarct at day 5
• use of mechanical assist device at day 5

MACMAN

In intensive care patients requiring orotracheal intubation, does video laryngoscopy (VL) compared to the Macintosh direct laryngoscope (DL) increase the frequency of first pass intubation?

MARIK

Does intravenous vitamin C, hydrocortisone and thiamine in addition to standard treatment, improve mortality in ICU patients with severe sepsis or septic shock, compared with standard treatment alone?

POCUS – Battlori

In patients undergoing internal jugular cannulation under ultrasound guidance, does the use of an oblique compared to short- and long-axis approach increase success rate and decrease complications?

POCUS – Kristensen

In medically-qualified anaesthetists, does the use of the transverse ultrasound technique compared to the longitudinal orientation result in faster identification of the cricothyroid membrane?

RENAL

In critically ill adults requiring renal replacement therapy, does higher intensity dialysis compared to lower intensity dialysis reduce mortality?

SIMONS

In adult ICU patients, does the use dynamic light therapy compared to normal lighting, reduce the incidence and duration of ICU-acquired delirium?

NIVAS

In patients who develop acute hypoxaemic respiratory failure after abdominal surgery, does non-invasive ventilation compared to standard oxygen therapy prevent the need for re-intubation?

OPERA

In patients who have undergone major abdominal surgery does the application of high flow nasal cannulae compared with standard oxygen therapy, decrease the incidence of hypoxemia at one hour after extubation?

RENAL

In critically ill adults requiring renal replacement therapy, does higher intensity dialysis compared to lower intensity dialysis reduce mortality?

SPARK

In critically ill patients, with mild renal failure, does furosemide infusion compared to placebo worsen kidney function?

 

TRICOPS

In cancer patients with septic shock does a restrictive vs. a liberal transfusion threshold reduce 28 day mortality?

URANGA

In hospitalised patients with community-acquired pneumonia (CAP), is five days of antibiotic therapy non-inferior to standard practice with respect to clinical improvement?

WOMAN

Does the early administration of tranexamic acid (TXA), compared with placebo, reduce death from bleeding in women with post-partum haemorrhage (PPH)?

XIAN SU

In elderly patients following non-cardiac surgery, does a low dose dexmedetomidine infusion, when compared with placebo, decrease the incidence of delirium?