A prospective study to assess the reliability of two haemodynamic tests, SIGH35 and end-expiratory occlusion test (EEOT), to predict fluid responsiveness in critically ill patients on PSV
SIGH35 vs EEOT: Fluid Responsiveness in ICU Patients
TESTS Trial
TESTS trial: thymosin α1's impact on 28-day mortality in sepsis
PanEcho Trial
Discover how PanEcho, an AI model, automates echocardiography interpretation with high accuracy, enhancing clinical workflows and patient care.
REST Trial
Impact of ECCO₂R on 90-Day Mortality in AHRF Patients
GASTROSAM
Safety and efficacy of high-volume intravenous rehydration for severe malnutrition and gastroenteritis in children.
NOTACS
Did high Flow Nasal O2 improve outcomes after cardiac surgery?
ANH for cardiac surgery
Saline Vs CSL on ICU - outcome differences?
FLUID Trial
Saline Vs CSL on ICU - outcome differences?
Biomarkers in ICU acquired weakness
Predictive biomarkers in ICU acquired weakness.
ENCOMPASS
Did the STAR programme enhance sepsis survivorship?
RESCUE-3
Did transvenous diaphragm stimulation aid weaning from ventilation?
TARGET Protein Trial
Does protein augmentation affect outcome amongst ICU patients?
UK-ROX
Does target SpO2 88-92% Vs SpO2 ≥96% reduce mortality in ventilated patients?
Driving Pressure and ARDS
Driving pressure and ARDS outcomes
MINT Trial
Was a liberal or restrictive transfusion strategy the way forward in MI and Anaemia?
Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients
SFY - Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients What was it? A multicenter, open-label, randomized clinical trial comparing dexmedetomidine-based and clonidine-based sedation versus propofol-based sedation (usual care) in critically ill patients on mechanical ventilation. The trial tested whether α2-adrenergic receptor agonist-based sedation reduces time to successful extubation. The Devil in... Continue Reading →
Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial
SFY - Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial What was it? This was a multicenter randomized trial comparing prolonged awake prone positioning (>12 hours daily for 7 days) with standard care (shorter prone positioning) in non-intubated COVID-19 patients with acute hypoxemic respiratory failure... Continue Reading →
