A prospective study to assess the reliability of two haemodynamic tests, SIGH35 and end-expiratory occlusion test (EEOT), to predict fluid responsiveness in critically ill patients on PSV
SIGH35 vs EEOT: Fluid Responsiveness in ICU Patients
TESTS Trial
TESTS trial: thymosin α1's impact on 28-day mortality in sepsis
PanEcho Trial
Discover how PanEcho, an AI model, automates echocardiography interpretation with high accuracy, enhancing clinical workflows and patient care.
REST Trial
Impact of ECCOâ‚‚R on 90-Day Mortality in AHRF Patients
GASTROSAM
Safety and efficacy of high-volume intravenous rehydration for severe malnutrition and gastroenteritis in children.
NOTACS
Did high Flow Nasal O2 improve outcomes after cardiac surgery?
ANH for cardiac surgery
Saline Vs CSL on ICU - outcome differences?
FLUID Trial
Saline Vs CSL on ICU - outcome differences?
Biomarkers in ICU acquired weakness
Predictive biomarkers in ICU acquired weakness.
ENCOMPASS
Did the STAR programme enhance sepsis survivorship?
RESCUE-3
Did transvenous diaphragm stimulation aid weaning from ventilation?
TARGET Protein Trial
Does protein augmentation affect outcome amongst ICU patients?
UK-ROX
Does target SpO2 88-92% Vs SpO2 ≥96% reduce mortality in ventilated patients?
Driving Pressure and ARDS
Driving pressure and ARDS outcomes
MINT Trial
Was a liberal or restrictive transfusion strategy the way forward in MI and Anaemia?
Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients
SFY - Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients What was it? A multicenter, open-label, randomized clinical trial comparing dexmedetomidine-based and clonidine-based sedation versus propofol-based sedation (usual care) in critically ill patients on mechanical ventilation. The trial tested whether α2-adrenergic receptor agonist-based sedation reduces time to successful extubation. The Devil in... Continue Reading →
Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial
SFY - Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial What was it? This was a multicenter randomized trial comparing prolonged awake prone positioning (>12 hours daily for 7 days) with standard care (shorter prone positioning) in non-intubated COVID-19 patients with acute hypoxemic respiratory failure... Continue Reading →
